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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Colonisation resistance ： ウィキペディア英語版 Colonisation resistance Colonization resistance is the mechanism whereby the intestinal microflora protects itself against incursion by new and often harmful microorganisms.〔Wilson, Michael. (''Microbial inhabitants of humans: their ecology and role in health and disease'' ). Cambridge University Press, 2005〕 Colonization resistance was first identified in 1967 and was initially referred to as antibiotic associated susceptibility. It was observed that animals being treated with the antibiotic streptomycin were susceptible to Salmonella enterica at doses 10,000 fold lower than the standard minimal infectious dose.〔http://jid.oxfordjournals.org/content/111/2/117.long〕 This led to investigations about the mechanisms utilized by endogenous microbial populations that conferred protection against exogenous pathogens attempting to colonize the gut floura. Recently, it has been observed that colonization resistance can occur within the host in a 'direct' or 'indirect' manner.〔http://www.nature.com/nri/journal/v13/n11/pdf/nri3535.pdf〕 The former refers to particular components of the microbiota directly competing with exogenous pathogens for nutritional niches (e.g. Bacteroides thetaiotaomicron directly competes with Citrobacter rodentium for carbohydrates in the intestinal lumen〔http://www.sciencemag.org/content/336/6086/1325.long〕) or by producing growth inhibitors (e.g. Bacteroides thuringiensis can secrete Bacteriocin that directly targets spore-forming Clostridium difficile thus inhibiting its growth through an unknown mechanism),〔http://www.pnas.org/content/107/20/9352.long〕 that directly inhibit the colonizing pathogen. Indirect colonization resistance is thought to be mediated through the induction of immune responses in the host that concomitantly inhibit the colonizing pathogen. An example of this has been observed with Bacteroides thetaiotaomicron which can induce the host to produce antimicrobial C-type lectins REGIIIγ and REGIIIβ, both anti-microbial peptides that target gram-positive bacteria.〔http://www.sciencemag.org/content/313/5790/1126.long〕 ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Colonisation resistance」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.